The Sextants Of Beijing Essay Research Paper free essay sample

The Sextants Of Beijing Essay, Research Paper A book The Sextants of Beijing by Waley Cohen view China from a Western point of position. In this book Chinese emperors, Chinese authoritiess, and Chinese people were engaged by the outside universe, and wanted to analyze and larn foreign goods and thoughts. However, at the same clip they were feared that they might lose political and moral every bit good as their Chinese values and traditions. In each chapter, the writer explained the overview of China # 8217 ; s contracts with other civilisations, how China participated in a web of international exchange all around the universe. In the book, it started out from the twelvemonth between 629 through 645, which was the Tang dynasty. In this clip, Han China was interested in set uping political and commercial relationships with others through trade. China began to merchandise silk and gold with Central Asia in regular footing and in return, China imported spices, woollen cloths, and military undertakings from India. We will write a custom essay sample on The Sextants Of Beijing Essay Research Paper or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Harmonizing to Waley Cohen, the trade expanded for a figure of grounds during the Tang dynasty. The first was merely the attraction of the success and cosmopolites Tang tribunal and society. The second was an addition in seafaring accomplishments and hazardous efforts that were learned through trade. The 3rd was the alteration of goods that the China was exporting. Skills that China learned was the most wanted merchandise for all the Chinese. However, ceramics began to up rise as the taking of exports and the trade of silk production lost when silkworm cocoons were smuggled out from China. Even though all right silks were remained in a great trade and were still traded around the universe, development of porcelain was much finer than earlier ceramics. Besides, during this period the most influential characteristics of the traffic were the spread of Buddhism from India to China. Along with them, they took elements of Confucianism and other cultural facets of Chinese civilisation. The China # 8217 ; s first indistinguishable interaction with Europe and European civilization was during the sixteenth through 18th centuries. The urbanisation added series of developments including the spread of literacy among both work forces and adult females, much wider abilities of books, attending to adult females for more instruction, and readying of civil service tests that were reserved for work forces. I think a connexion between China and Europe brought China a great trade of spread outing their abilities of survey. Many people rose in upper category and began to cod art objects and old-timers on a much larger graduated tables. Besides between the China and Europe in the early modern age took topographic point through the Jesuit missionaries. In the late seventeenth and 18th centuries, the connexion of trade through Southeast Asia and the trade linked to European states through their colonial activities in Asia. The Qing imperium didn # 8217 ; t want to let Europeans to entree China # 8217 ; s market but they played a cardinal portion in Qing imperium, which represented a major political and cultural force in the part. Besides in the 18th century, the commercialism played an of import function. The trade brought China some necessities such as Piper nigrum, coconut oil, rice, sugar, degree Celsius opper, wood, Calamus rotang, and sea bullets and took Chinese ceramics, fabrics, and other installations. China made a trade with Japan, the Ag and Cu from Nagasaki, the lone port unfastened to foreign trade in Japan, even though China and Japan were unfriendly to each other. However, the changeless demand of Cu and Ag to China made them trade with Japan. After the decease of Qianlong in 1799, China suffered the series of pacts that were unequal, and gave the Western powers and rights in China. Besides by the 19th century, many educated Chinese learned their civilization profoundly because any faiths within the Chinese traditions seemed unimportant to both the Western and Nipponese imperialism. China wanted to follow Western ways to get the better of the West and wanted to continue its ain civilisation. Since so in the 19th century, China became some how alone. About one hundred ports in China opened to foreign trade. Japan and Western powers competed to set up a field of influence from China. Besides during the period of the foreign powers, China was forced by them efficaciously to construct railway, excavation, and timber rights. By the terminal of the century, railwaies and telegraphs helped distribute information about the foreign presence into the inside of China. At this clip, China hoped to choose and follow the Western ways to get the better of the West and to continue its ain civilisation. To analyze and learn more about the West, Chinese started to travel out to overseas and increased their experience of survey. In the late teens and early mid-twentiess, it was the clip for 2nd and besides the 3rd coevalss for immature Chinese to analyze in abroad. Not merely the figure of adult females who studied in abroad were increased, but besides their environment changed. The new tendency of geting cognition and gaining powers from the West was effectual to vie. The purpose of the Chinese to analyze in the West was to convey place the cognition of Western engineering. Even though Chinese pupils had some troubles, they went all over the universe to analyze. Among France and Britain, many Chinese pupils preferred to analyze in Japan since they offered sense of shared civilisation. Besides many people idea it would be a cutoff to analyze in Japan to derive Western cognition because the modernisation was more advanced than China # 8217 ; s. When they were outside of their state, Chinese pupils enjoyed much greater freedom of idea and freedom of looks about anything and about their traditions than when they were back place. If the Chinese wanted to larn about the West, it would be better for them to larn straight from the West. However, since Japan was nigh and they had Asian pride, most remained in Asia and studied in Japan. These experience for international relationship brought China a great position and gained many ideas. For taking the hazard of traveling out to abroad led them achieve a batch of cognition and engineering. They adopted the system of international pacts as a mean of set uping Chinese diplomatic representation overseas. China ever wanted to be a centre of attending so those attempts made China go civilised province.

Foreign Market Entry Strategies Essay Essays

Foreign Market Entry Strategies Essay Essays Foreign Market Entry Strategies Essay Essay Foreign Market Entry Strategies Essay Essay When an organisation has made a determination to come in an abroad market. there are a assortment of options open to it. These options vary with cost. hazard and the grade of control which can be exercised over them. The simplest signifier of entry scheme is exporting utilizing either a direct or indirect method such as an agent. in the instance of the former. or countertrade. in the instance of the latter. More complex signifiers include foreign direct investings which may affect joint ventures. or export processing zones. Having decided on the signifier of export scheme. determinations have to be made on the specific channels. : Many agricultural merchandises of a natural or trade good nature usage agents. distributers or affect Government. whereas processed stuffs. whilst non excepting these. rely more to a great extent on more sophisticated signifiers of entree. These are discussed in this paper. The three chief ways are by direct or indirect export or production in a foreign state. Exporting Exporting is the most traditional and good established signifier of operating in foreign markets. Exporting can be defined as the selling of goods produced in one state into another. Whilst no direct fabrication is required in an abroad state. important investings in marketing are required. The inclination may be non to obtain as much elaborate selling information as compared to fabrication in marketing state ; nevertheless. this does non contradict the demand for a elaborate selling scheme. Here the fabrication is home based therefore. it is less hazardous than overseas based. Besides giving an chance to â€Å"learn† abroad markets before puting in bricks and howitzer. it besides reduces the possible hazards of operating overseas. Exporting methods include direct or indirect export. In direct exporting the organisation may utilize an agent. distributer. or abroad subordinate. or act via a Government bureau. The disadvantage is chiefly that one can be at the â€Å"mercy† of abroad agents and so the deficiency of control has to be weighed against the advantages. For illustration. in the exportation of African horticultural merchandises. the agents and Dutch flower auctions are in a place to order to manufacturers. Harmonizing to Collett3 ( 1991 ) exporting requires a partnership between exporter. importer. authorities and conveyance. Without these four coordinating activities the hazard of failure is increased. Contracts between purchaser and marketer are a must. Forwarders and agents can play a critical function in the logistics processs such as booking air infinite and set uping certification. Foreign direct investing Besides exporting. other market entry schemes include licencing. joint ventures. contract industry. ownership and engagement in export processing zones or free trade zones. Licensing: Licensing is defined as â€Å"the method of foreign operation whereby a house in one state agrees to allow a company in another state to utilize the fabrication. processing. hallmark. know-how or some other accomplishment provided by the licensor† . It is rather similar to the â€Å"franchise† operation. Coca Cola is an first-class illustration of licensing. In Zimbabwe. United Bottlers have the license to do Coke. Licensing involves small disbursal and engagement. The lone cost is subscribing the understanding and patroling its execution.

Timeline of 15th Century Inventions

Timeline of 15th Century Inventions Most people know that Johannes Gutenberg invented movable type presses during the 15th century- in 1440 to be exact. That invention, which was possibly historys greatest, made the inexpensive printing of books possible. But, many other important inventions were introduced  during this century. Below are those that top the list. Early 1400s: Golf, Music, and Painting Tiger Woods,  Arnold Palmer,  and  Jack Nicklaus  would never have walked the links without the invention of the little white ball that they smacked incredible distances. Wolfgang Amadeus Mozart  could never have composed his classic concertos without a piano. And, imagine the  Renaissance  without oil painting. Yet, these world changing inventions were created in the early 1400s.   1400: Golf is thought to have originated in a game played in Scotland as early as 1400. The balls were made of wood and didnt travel very far, but at least they represented a start. Indeed, golf was so entrenched in Scotland by midcentury that in 1457,  King James II of Scotland  issued a ban  against playing the game.The earliest version of the piano, called a clavichord, came into existence this year, according to the website, Piano Play It. In 1420, the clavichord  gave way to the harpsichord and leter the spinet, which looks more like the pianos used today.1411: Technically called the matchlock, the trigger- the basic firing mechanism for a rifle or gun- first appeared this year.1410: Oil paint, itself, was actually invented in Asia sometime before the fifth century, but oil painting techniques- like those used by such great artists as  Leonardo da Vinci  and  Michelangelo- were introduced this year by  Jan van Eyck.1421: In Florence, Italy, hoisting gear was inve nted.1439/1440: Gutenberg invents the printing press. Midcentury: Printing Press, and Glasses You would not be reading this website if it were not for Gutenbergs invention of the printing press, upon which all modern typed material is based- including printed material on the web. And, many of you would not be able to read this page without glasses. The rifle also- sadly- advanced during this period. 1450: Nicholas of Cusa created spectacles of polished lenses for nearsighted people.1455: Gutenberg introduced the printing press with metal movable type, marking a turning point in world history.1465: In Germany, drypoint engravings came into existence.1475: Muzzle-loaded rifles were invented in Italy and Germany. Late 1400s: The Parachute, Flying Machines, and Whiskey Many of the ideas and devices common in modern times came into existence in this time period. Some, like the parachute or flying machines, were merely drawings inked on a page by Da Vinci. Others, such as the globe, helped humans navigate the world, and whiskey became a popular drink in the U.S. and worldwide. 1486: In Venice, the first known copyright was granted.1485: Da Vinci designed the first parachute.1487: Bell chimes were invented.1492: Da Vinci was the first to seriously theorize about flying machines.Martin Behaim invented the first map globe.1494: Whiskey was invented in Scotland. Resources and Further Reading â€Å"Early Piano History.† Edited by Ashwati Franklin, Piano Play It, 2017. Highfield, Roger. â€Å"Oil Painting Invented in Asia, Not Europe.† The Telegraph, Telegraph Media Group, 22 Apr. 2008. â€Å"The Matchlock.† The Encyclopedia of Weapons, 22 June 2011. â€Å"Oil Paint History.† Cyberlipid, Les Sites De GERLI.

Administrative Ethics Essay Example | Topics and Well Written Essays - 500 words

Administrative Ethics - Essay Example However, once that is established, the first dictum of the ASPA code of ethics tells us that service to the public is above service to oneself and that certainly applies in this case. If one is to remain quiet about this it is certainly possible that the boss would be very pleased and Tristate would also be very happy. Of course, there are plenty of vested interests in the construction of the mall simply because a lot of people have a lot to gain from the construction. It is basically a project worth billions of dollars to all the stakeholders and they are essentially serving themselves. Therefore, if we are to follow the code of ethics given by the ASPA, we have to consider what the best course of action would be to preserve the interest of the public. In this case, we can come with two different options of which the first option would be to report the matter to the higher authorities and see what they decide to do with it. Reports to the committee or reports to the council about the incident could be very useful in making sure that the right people have the right information about what is going on concerning the megamall project. In fact, the information could even be taken to the media since that would be more than likely to put an immediate halt to the process. The second option would be to see if the construction of the mall is really towards the benefit of the public. For example, there are many jobs to be created in the mall for the local community with white collar positions such store managers, financial accountants, legal advisors, logistics managers and several other managerial positions that would be needed by companies who setup operations in the mall. For the blue collared workers, there would be jobs in food courts, restaurants, mall security and other store positions that would do a lot for the economy of the region. Thus the public certainly has something to gain from the mall being there. The decision therefore becomes to tell or not

Managing Human Resources Research Paper Example | Topics and Well Written Essays - 250 words

Managing Human Resources - Research Paper Example Lastly, he/she should be able to handle conflict and always have an eye towards how to mediate a given situation amicably. Q2: A human resource director is not only charged with managing the day to day process flow of human resources but also molding and directing the future form that the company wishes to take. This happens in a variety of different ways but most importantly through selecting and testing new prospects to ensure they are an adequate fit for the firm in question. In the given question concerning choosing the correct employee to fill a position as bank teller, the HR manager should look for someone with a customer service background, cheerfulness, ability to handle responsibility, trustworthiness, clean record, and exceptional people skills (Holland, 2012). Q3: With respect to working closely with the business strategy arm of a given institution, this is an integral part of HR’s role and responsibility. Many firms overlook this integral part to their own detriment. HR can work to quickly mirror the goals and strategies that a company lays out for its employees. Human resources can take this responsibility so that each of the internal departments continues to function at peak efficiency; all the while the new goals and metrics can be implemented across the organization at a speed and efficiency that would not have been possible had each of the departments attempted to implement on their own time and in their own way. Ployhart, R. E., Van Iddekinge, C. H., & Mackenzie Jr., W. I. (2011). ACQUIRING AND DEVELOPING HUMAN CAPITAL IN SERVICE CONTEXTS: THE INTERCONNECTEDNESS OF HUMAN CAPITAL RESOURCES. Academy Of Management Journal, 54(2), 353-368.

Optically Active Pharmaceutical Compounds Biology Essay

Optically Active Pharmaceutical Compounds Biology Essay The molecules which are non super imposable mirror images of one another are termed as chiral. These are a pair of enantiomers and are diasymmetric as well as optically active. Since they promote optical rotation, these enantiomers are also known as optical isomers. These chiral molecules consist of a tetrahedral carbon atom which is attached to four different groups. The carbon atom is the stereogenic or the asymmetric centre of the molecule. The enantiomers are similar in their physical and chemical properties in an achiral environment. Enantiomers have different biological properties. This influences the efficacy and the toxicity of the compounds. Usually, one of the enantiomers is bioactive and the others may be inactive or toxic. Example, Verapamil is a calcium channel blocker used for the treatment for blood pressure, angina. The (S) isomer treats the increase in BP more effectively than the racemate form. The (R) isoform inhibits resistance of cancer cells to anti cancer drugs (Crosby, 1991). The enantiomerically pure compounds are very useful and vital in the pharmaceutical and agrochemical industries. It has also been shown that the optically pure and chiral compounds should be used rather than mixture of enantiomers. The optically active pure compounds are used to produce antibodies, hormones, anti inflammatory, amino acids, vitamins, anti cancer drugs, cardiovascular drugs. Chiral chromatography or ligand exchange chromatography was an analytical technique used for separating enantiomers. High performance liquid chromatography whereby chiral stationary phase is used was efficient in separation of enantiomers. The optically active ligands like amino acids are bound covalently to a solid support, thereby forming a chiral stationary phase. Various amino acid derivatives like N -(3,5-dinitrobenzoyl) phenyl glycines are also used.(Pirkle and Pochapsky,1987). The major advantage of chromatography is that it results in high enantiomeric excess and is suitable on the analytical scale. However, its drawback is that the scale up is difficult. The production of enantiomers for optically active drugs may be produced by different methods. Pure compounds are recovered by various extraction techniques from chiral compounds (alkaloids, carbohydrates) exist as pure enantiomers naturally. Fermentation of cheap substrates which are available in abundance (like molasses and sucrose) was a widely used source of single chiral molecules lactic, tartaric and L- amino acids and also for complex substances which include vitamins, antibiotics and hormones.(Buchta,1983). Optically pure compounds may be prepared from inactive starting materials by asymmetric synthesis and resolution of racemates. In the process of asymmetric synthesis (Stinson,1993) an enantiomeric reagent or catalyst is used for carrying out a specific reaction on an achiral substrate (prochiral) to produce a single chiral product. Overall, it is a selective technique as it leads to product selectivity. Its disadvantages are that it may be expensive due to the numerous steps involved and also because of the use of costly enantiomeric reagents. It is cheaper to produce a racemic mixture and then separate the enantiomers by physical methods like kinetic resolution or diastereomeric crystallization. Covalent derivatives are formed using optically pure resolving agents in the diastereomic crystallization method. The drawback is that it is wasteful since the unwanted isomer may be discarded. On the other hand, kinetic resolution is based on the principle that two enantiomers react at vari able rates in the presence of a chiral catalyst like an enzyme. This method involves product selectivity. Biotransformation has also become a key technology used to produce chiral substances. It was used by many companies Eg. Celgene Corporation developed procedures to produce amines by using amino transferase (Celgene corporation,1990).The main advantage of this procedure is that it allows 100% theoretical conversion of the substrate into the final product. Membrane chirotechnology is also a widely used method for producing optically pure isomers. In this procedure, the membrane itself maybe intrinsically enantioselective. This means that the membrane represents a chiral system that separates the desired isomers on the basis of spatial conformation. On the other hand, a membrane separation process may be combined with kinetic resolution by making use of an enantiospecific biocatalyst.That is, the membrane helps in the separation of the product from the substrate on the basis of their chemical properties like solubility. Enantiospecific catalytic membrane reactors may also be used. These comprise of membrane processes which are advantageous as they have the ability to work in a continuous mode and enormous amounts of material could be processes at once. The competitive production of chiral substances requires a large scale, cheap process for the production and separation of the enantiomers. Eg. Pyridoxal phosphate dependant lyase and transferase were used as catalyst in the synthesis of L- amino acid via the carbon carbon bond formation. (Sheldon,1993) The widely used enantiospecific membrane reactors are ultrafiltration hollow fibre membrane reactor (Responsible for production of L phenylalanine by using dehydrogenase catalyst (Schimdt et al, 1987) ) immobilized enzyme membrane reactor, packed bed continuous bioreactor, biphasic membrane reactor etc. Ultra filtration, electrodialysis and membrane extraction are common separation processes that are combined with biotransformation. Matson and Quinn(1979) showed the optimization in production of amino acids enantiomers and studied the separation of L amino acids from the racemate solution by making use of an impregnated liquid membrane alone with an enzyme immobilised membrane. Production of L-phenylalanine from racemic mixture of D,L phenyl lactate was shown by 2 consecutive biotransformation in an enzyme membrane reactor whereby the enzyme and cofactor(NAD/H) had been compartmentalised behind an ultra filtration membrane.(Schmidt et al, 1987). Intrinsically enantioselective membranes are also widely used. Substances which are optically active can be separated on the basis of there physical stereo selectivity. Polymeric membranes having the enantioselective properties intrinsically may be prepared making use of chiral polymers or by chiral modifications of the achiral porous membrane in the presence of chiral recognition agent like cyclodextrins, cyclophane and oligopeptides. In order to prepare the enantioselective membranes, optically active polyacryl amides and cellulose derivatives may be used. Yoshikawa et al,1996, showed separation of tryptophan, phenylalanine and alanine by ultra filtration using the chiral selector which was molecularly imprinted polymeric membranes(DIDE derivatives). Enzymes have the ability to catalyse a broad spectrum of chemical reactions with great efficiency and selectivity under mild and environmentally friendly conditions. By exploiting the selectivity of enzymes for one form of the enantiomer of a racemic mixture, the enantiomerically enriched compound can be obtained by biocatalytic resolution.(Thomas et al,2002) Most commonly, the hydrolytic enzyme are used since they display a range of advantages like stability, specificity, no requirement of cofactors. Among hydrolases, lipase is most commonly used because of high enantioselectivity, commercial availability and good stability in various media.(Seung Hwan et al,2004) Recently a new technique was introduced to display the peptides and proteins on the surface of gram negative and gram positive bacteria, yeast or mammalian cells. This was done by fusing the peptides to surface anchoring motif; and the technique is known as cell surface display. The cell surface display lipase proved to be an excellent biocatalytic system for the kinetic chiral resolution of the racemic compound. Recent advances have shown the use of enzymes in the synthesis of optically pure drugs and biologically active compounds. Enzymes have the ability to distinguish between the enantiomers of racemic substrates. Various strategies have been developed to improve the stereoselectivity of resolutions catalysed by the enzyme. This includes modification of the substrate, recycling of the product and altering the reaction conditions. By making use of these strategies, enzymes with modest stereoselectivity can also be used but only one enantiomer is produced with high yield. Enzyme can catalyse transformations with high region selectivity and chemo selectivity under mild reactions. This is important in the modification of chiral drugs. Eg. Penicillin acylase causes the hydrolysis of benzyl penicillin without affecting the beta lactam ring and allows the industrial preparation of 6-aminopenicillanic acid which is a precursor for many semi synthetic penicillins. Enzymes (hydrolases) have success fully been used in the synthesis of chiral pharmaceuticals, however modern methods of protein engineering and industrial microbiology help in the production of enzymes which are more inexpensive, stable with broad substrate specificity and high stereoselectivity.(Alexey L.Margolin,1993) Catalytic asymmetric synthesis is the asymmetric synthesis that is catalysed by chiral (transition) metal complex. The reactions that are involved are Redox transformations or carbon carbon bond forming processes that complement enzymatic hydrolytic process. The three types of chemo catalysts that exist are heterogenous metal catalyst, homogenous complex and soluble chiral acid or bases. Emil Fishers work on asymmetric induction which was based on cyanohydrin synthesis was the first reaction subjected to asymmetric catalysis. Enantiomerically pure amino acids, amino alcohols, amines, alcohols and epoxides play an important role as intermediates in the agrochemical and pharmaceutical industry whereby high level of purity and a large quantity is required. The enantiomerically pure active compounds help in improving the economics of the process, thereby leading to reduced quantities applied and less amount of an environmental impact. Chemical process for the manufacturing of amino acids: Even though asymmetric syntheses of amino acids are known (Michael Breuer et al,2004), no economical process has been developed. Bucherer Bergs sub type which is Strecker synthesis was employed for the industrial manufacturing of the racemic amino acids. The alpha amino nitrile is produced from hydrocyanic acid, ammonia and an aldehyde and may be hydrolysed to the amino acid directly or in the presence of carbon dioxide it gets converted into hydantoin. The hydantoin is then subjected to hydrolysis in a basic media to give the racemic amino acid. Another route to the racemic amino acid is amido carbonylation in the presence of a transition metal. Although, there is no commercially viable chemical process for the synthesis of enantiomerically pure amino acid, the production of racemic amino acid is still of great importance because the racemates may be converted to enantiomerically pure compounds by various biocatalytic methods. The catalysts used in the biotransformation are metabolically inactive cells or isolated enzymes. It is the method of choice for the production of enantiomerically pure D- amino acids and various other non natural amino acids. Lyases may be used as biocatalysts in the production of L- Aspartic acid from fumaric acid (Beller et al,2000). Amino acid dehydrogenase (deaminating amino acid oxido reductase) allows enantioselective biotransformation on an industrial scale. These enzymes have low substrate specificity due to which non natural compounds may also be transformed. In addition, they also require co substrates which help in supplying the hydride ions for the reduction of Schiff base. There is also a chemo enzymatic method for amino acid synthesis. In this, L- amino acid gets oxidised by L- amino acid oxidase. Imine (intermediate) gets reduced by Pd-C in ammonium formate buffer. In the resulting racemic mixture, only L enantiomer is utilised by oxidase where as the D- enantiomer accumulates. Therefore, the enantiomeric form of the amino acid which is produced depends entirely on the specificity of the oxidase. The enantiomerically pure amino acid can also be prepared by the racemate resolution. Eg: L and D amino acid can be prepared with the Hydantoinase-carbamoylase system. Production of carboxylic acids: Carboxylic acid can be isolated from natural sources(chiral pool).Naturally occurring chiral compounds obtained from the chiral pool are an alternative to the synthesis of enantiomerically pure products. An examples of a chiral carboxylic acid that is isolated from the natural sources is L (+) tartaric acid (Mitsugi et al,1978). During the fermentation of grape, the isomeric form of tartaric acid separates out as tartarate (potassium hydrogen tartarate).On reacting with calcium chloride or calcium hydroxide and sulphuric acid, isomeric tartaric acid is released; gypsum and yeast residues occur as the by products. Natural carbohydrate building blocks were used for several decades for the preparation of sugar acids which were enantiomerically pure. Another method is the classical chemical synthesis which involves crystallization with enantiomerically pure amines. The enantiomers of the racemic carboxylic acids are known to separate by fractional crystal lization of the diastereomeric salts which are formed with the enantiomerically pure amines. Eg: Thiazolidine carboxylic acid (enantiomerically pure), an intermediate in the synthesis of CP-060- S is isolated by the resolution of racemate with N- benzyl-1-phenylethylamine. (Pompejus et al, 2001) Production of amines: The chemical process involved is the crystallization with chiral carboxylic acids. Isolation of enantiomerically pure amines can be carried out by the crystallization of diastereomeric salts of chiral carboxylic acids with chiral amines (Jacques et al,1980). Thus (R) or (S) 1- phenylethlyamine may be produced on an industrial scale by the crystallization with either (R)- mandelic acid or (S)- malic acid. Mandelic acid was shown to be an important resolving agent for numerous numbers of amines. Dutch resolution is a variant of the classical racemate resolution. In order to reduce the search for an appropriate resolving agent for an amine through combinatorial approach, a mixture of many optically active acids were used. The salt that was precipitated contained several acid anions. Production of optically active amino alcohols: (S)-2-Aminobutanol is an important amino alcohol intermediate which is used for the synthesis of ethambutol (tuberculostatic)and it must be administered in its enantiomerically pure form as it may lead to blindness. The enantiomerically pure form can be obtained from the racemate by carrying out the crystallization with L-Tartaric acid.(Sheldon et al,1993) Production of alcohols: The main process involved was the asymmetric hydrogenation of ketones. Noyori et al showed the development of asymmetric hydrogenation of keto esters and ketones. The catalysts used were ruthenium complexes of binap and derivatives like tol-binap (Akutagawa,1995)and segphos. The biotechnological process is mainly the enzyme catalysed resolution. For the resolution of racemate alcohols, enzymatic acylations were developed in early 1980s.The racemic alcohols are made to react with an acylating agent under enzyme catalysis whereby one enantiomer is unconverted whereas the other enantiomer is esterified. The biocatalysts used are bacterial and fungal lipases. Production of epoxides: This includes sharpless asymmetric dihydroxylation. The route to the formation of chiral epoxides is based on the optically active diols which may be converted to their respective oxiranes. Another method is the Jacobsen asymmetric epoxidation which is based on (salen) manganese III precatalyst and the hypochlorite is used as the stoichiometric oxidizing agent. The chemical processes may be compared with the biotransformation with respect to the environmental impact and economic efficiency. The drawbacks of the chemical routes are solvent emission or toxicity of certain compounds. On the other hand, chiral technologies are developing rapidly. Highly versatile technologies and procedures are introduced. Most chiral intermediates are produced in minute quantities. Therefore, the criteria that should be considered for the methods introduced are that they should have a broad substrate spectrum, not require specialised equipment and have a cost effective access to a range of products. It is not possible to make general conclusions about the superiority of one type of technology in comparison with the others. The most economic technique will depend on their component which is why each case should be investigated individually. However, in the overall process, the chiral step should be introduced as early as possible but this may be hindered by other factors like racemisation of the unwanted isomer. Membrane chirotechnology is also an emerging technique having several advantages with respect to the purity of simple isomers, productivity and ease of scale up. These techniques have mainly been used at the laboratory scale. Application on a large scale needs more investment especially in developing the experimental set up rather than investigations which have been carried out on chirality that have been developed in the chromatographic field.

HCS/466 Facility Planning I Essay

Strategic Planning is an essential first step in the development of a result-base accountability system,† (Schilder, 2013, p. 1). In strategic planning an organization must know their goals, missions, and how to reach them. Health care facilities are in huge demand for the elderly and for people who lives in low-income communities. A person who receives good quality health care services can prevent the spread of contagious diseases. This paper will describe the need of the community, population it is serving, and a brief description of the facility. Franklin C. Fetter Family Health Center (FCFFHC) is an outpatient clinic and has served the communities, and the surrounded rural areas since 1975. This health center is greatly needed in the rural and low-income communities because the people could not get to their local hospital. Therefore, the people in those communities were not getting the necessary medical health care needed. Dr. Franklin C. Fetter, the Dean of Medicine at the Medical University of South Carolina, and founder, provided culturally sensitive comprehensive primary health and home care services to children, and adults as part of a demonstration grant under the Medical University in 1968, (FCFFHC, 2013). The center offers support to the community by sponsoring health awareness campaigns, health fairs, and through their media. The most important need that the elderly community needed was a Home Health Department (FCFFHC, 2013). This department provides services to home bound people who cannot travel to see the doctor. Home Health have a staff of one medical doctor, physician assistant, and a nurse practitioner. According to Roberta Porterfield RN, and Home Health Manger, â€Å"The object of home health staff is to assist patients in need of intermittent skilled nursing care to arrive at a stable level of health through treatment, while teaching and involving the patients’ family,† (Porterfield, FCFFHC, 2013, p.1). The medical facility operates eight primary health sites for the residents of Berkeley, Charleston, Colleton, and Dorchester counties. The centers hours are Monday – Friday, 8 a.m. – 8 p.m. â€Å"Franklin C. Fetter mission is to provide quality, affordable, culturally sensitive comprehensive primary health and home care services to families throughout their community and surrounding areas,† (FCFFHC, 2013, p. 1). , ‘ Franklin C. Fetter Center’s services includes: (FCFFHC, 2013) Prenatal Care Infant and Adolescent Care Adult and Geriatric Care Behavioral Health Breast Examinations Cervical Cancer Screening Skilled Home Health Service Prenatal Care (OB/GYN) EPSDT/ Immunizations Family Planning The health center offers many more services to the local community (FCFFHC, 2013). The population that FCFFHC provide medical care services to is 19,325 of rural and low-income people. The Health Center serve people of all ages from newborns to adults. Patients with insurance are require to present their insurance card before he or she receive services. Patients are expect to pay the co-payment or co-insurance. Patients without insurance at 100% of poverty level are require to pay a minimum of $30. Patients who pay for his or her services are require to pay, according to the sliding fee of $40, $50, or $60. The Health Centers’ sources of revenue are generated from: Fees-for-Service, Medicare, Medicaid, Private Insurance, and Grant Funds (FCFFHC, 2013). The newest facility was built in the spring, 2013. The center is in Yonges Island, South Carolina. This is a rural and remote area with mostly elderly people with little or no income. A health care facility existed where the new site is but had to be torn down because it needed severe repair. It is a one story brick building. The clinic has a patient registration that is adjacent to the Medical Records department. The Admitting front desk consisted of two receptions who check in the patient to see his or her provider. The appointment clerk is next to the Front desk. The appointment receptionists are the people who schedules everyone appointment and cancel a no show appointment. The Pharmacy is behind the Front desk personnel. The pharmacy provides the patients with low cost medicine based on a sliding fee. The nursing department and the physician’s office are behind the â€Å"DO NOT ENTER† sign. The health clinic have a total of seven adult examination room, and four pediatric rooms. The lab is behind the nursing station in the back of the facility. The medical center have a staff of 35 people. Building new health care centers in low income and rural areas will have a huge influence on families in the community. Getting good quality health care services are essential to the everyday living. It would make the people in the community feel as if someone cares about him or her. When a community is left with nowhere to get any medical services, they tend to deal with whatever health issues he or she may have. Not possessing access to medical care can sometimes lead to terminal illness and maybe death. Families would be able get the medical services that he or she needed for his or her family. References Franklin C. Fetter Family Health Care Center, Inc.: Home Retrieved from http://www.fcfetter.com Schilder, D. (2013). Strategic Planning Process; Steps in Developing Strategic Planning. Retrieved from http://www.hfrp.org/publications-resources/browse-our-publications/strategic-planning-proc..